Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis

23 Jan 2017Ganesan VelmuruganEmail author, Tharmarajan Ramprasath, Krishnan Swaminathan, Gilles Mithieux, Jeyaprakash Rajendhran, Mani Dhivakar, Ayothi Parthasarathy, D.D. Venkatesh Babu, Leishman John Thumburaj, Allen J. Freddy, Vasudevan Dinakaran, Shanavas Syed Mohamed Puhari, Balakrishnan Rekha, Yacob Jenifer Christy, Sivakumar Anusha, Ganesan Divya, Kannan Suganya, Boominathan Meganathan, Narayanan Kalyanaraman, Varadaraj Vasudevan, Raju Kamaraj, Maruthan Karthik, Balakrishnan Jeyakumar, Albert Abhishek, Eldho Paul, Muthuirulan Pushpanathan, Rajamani Koushick Rajmohan, Kumaravel Velayutham, Alexander R. Lyon and Subbiah Ramasamy

Organophosphates has gut microbiome-mediated diabetogenic nature and hence that the usage of these insecticides should be reconsidered.

Cross-section study
1 effect
3080 subjects

Reported Outcomes

CausesOutcomeCertainty

Pesticides Exposure Contaminant risk & protective factor

Diabetes Lymphatic outcome
Strong increased risk of Diabetes
Lymphatic system

Low evidence
167.0%