Associations between specific autoimmune diseases and subsequent dementia: retrospective record-linkage cohort study, UK

01 Mar 2017Clare J Wotton, Michael J Goldacre

The associations with vascular dementia may be one component of a broader association between autoimmune diseases and vascular damage. Though findings were significant, effect sizes were small. Clinicians should be aware of the possible coexistence of autoimmune disease and dementia in individuals.

Cohort Study
4 effects
13 years
1 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Dementia Brain outcome
Dementia
Brain system

Multiple Sclerosis Nervous outcome
Minor increase risk of Multiple Sclerosis
Nervous system

Moderate evidence
1.97%

Dementia Brain outcome
Dementia
Brain system

Psoriasis Intergumentary outcome
Minor increase risk of Psoriasis
Intergumentary system

Moderate evidence
1.29%

Dementia Brain outcome
Dementia
Brain system

Lupus (Systemic lupus erythematosus) Lymphatic outcome
Minor increase risk of Lupus (Systemic lupus...
Lymphatic system

Moderate evidence
1.46%

Dementia Brain outcome
Dementia
Brain system

Addison's disease Endocrine outcome
Minor increase risk of Addison's disease
Endocrine system

Moderate evidence
1.48%