Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

14 Feb 2017Connor A. Emdin, DPhil, Amit V. Khera, MD; Pradeep Natarajan, MD

A genetic predisposition to higher waist-to-hip ratio adjusted for body mass index was associated with increased risk of type 2 diabetes and coronary heart disease. These results provide evidence supportive of a causal association between abdominal adiposity and these outcomes.

Cross-section study
4 effects
111 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Obesity Musculoskeletal outcome
Obesity
Musculoskeletal system

Type 2 Diabetes Lymphatic outcome
Minor increase risk of Type 2 Diabetes
Lymphatic system

Low evidence
77.0%

Obesity Musculoskeletal outcome
Obesity
Musculoskeletal system

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Minor increase risk of Coronary Heart Diseas...
Cardiovascular system

Low evidence
46.0%

Visceral fat Digestive outcome
Visceral fat
Digestive system

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Minor increase risk of Coronary Heart Diseas...
Cardiovascular system

Moderate evidence
46.0%

Visceral fat Digestive outcome
Visceral fat
Digestive system

Type 2 Diabetes Lymphatic outcome
Minor increase risk of Type 2 Diabetes
Lymphatic system

Moderate evidence
77.0%