Preconception low-dose aspirin restores diminished pregnancy and live birth rates in women with low grade inflammation: a secondary analysis of a randomized trial

03 Feb 2017Lindsey A. Sjaarda, PhD Rose G. Radin, PhD Robert M. Silver, MD Emily Mitchell, PhD Sunni L. Mumford, PhD Brian Wilcox, MD Noya Galai, PhD Neil J. Perkins Jean Wactawski-Wende Joseph B. Stanford, MD Enrique F. Schisterman, PhD

In women attempting conception with elevated hsCRP and prior pregnancy loss, daily low dose aspirin may increase clinical pregnancy and live birth rates to those of women without inflammation and reduce hsCRP elevation during pregnancy.

Randomized Controlled Trial
1 effect
1228 subjects

Reported Outcomes


Aspirin Manufactured risk & protective factor
Minor Protective Factor Aspirin

Pregnancy & Birth Maternity outcome
Minor increase risk of Pregnancy & Birth
Maternity system

Moderate evidence