St John's wort for depression—an overview and meta-analysis of randomised clinical trials

13 Aug 1996Klaus Linde, scientific assistanta, Gilbert Ramirez, codirectorb, Cynthia D Mulrow, professor of medicineb, Andrej Pauls, consultant psychiatristc, Wolfgang Weidenhammer, biostatisticiana, Dieter Melchart, project leader

There is evidence that extracts of St John's wort are more effective than standard anti-depressans for the treatment of mild to moderately severe depressive disorders.

Meta Analysis
1 effect
1757 subjects

Reported Outcomes


St John's wort (Hypericum perforatum) Herb risk & protective factor

Depression Brain outcome
Decreased risk of Depression
Brain system

High evidence