Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure

16 Dec 2014Natalia V. Solenkova, MD, PhD, Jonathan D. Newman, MD, MPH, Jeffrey S. Berger, MD, MS, George Thurston, ScD, Judith S. Hochman, MD, Gervasio A. Lamas, MD

There is strong evidence that xenobiotic metal contamination is linked to atherosclerotic disease and cardiovascular disease and is a modifiable risk factor.

Meta Analysis
19 effects
60000 subjects

Reported Outcomes

CausesOutcomeCertainty

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Cardiovascular Disease Cardiovascular outcome
Strong increased risk of Cardiovascular Disease
Cardiovascular system

Low evidence
463.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Increased risk of Heart Attack (Myocard...
Cardiovascular system

Low evidence
66.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Strong increased risk of Coronary Heart Diseas...
Cardiovascular system

Low evidence
737.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Stroke Brain outcome
Strong increased risk of Stroke
Brain system

High evidence
151.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Mortality Musculoskeletal outcome
Increased risk of Mortality
Musculoskeletal system

High evidence
25.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Mortality Musculoskeletal outcome
Strong increased risk of Mortality
Musculoskeletal system

Low evidence
152.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Blood Pressure - Hypertension Cardiovascular outcome
Minor increase risk of Blood Pressure - Hype...
Cardiovascular system

High evidence
8.0%

Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Mortality Musculoskeletal outcome
Increased risk of Mortality
Musculoskeletal system

High evidence
28.0%

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Increased risk of Heart Attack (Myocard...
Cardiovascular system

High evidence
89.0%

Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Increased risk of Coronary Heart Diseas...
Cardiovascular system

High evidence
36.0%

Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Cardiovascular Disease Cardiovascular outcome
Increased risk of Cardiovascular Disease
Cardiovascular system

High evidence
36.0%

Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Stroke Brain outcome
Minor increase risk of Stroke
Brain system

High evidence
18.0%

Mercury Contaminant risk & protective factor
Mercury
Contaminant

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Increased risk of Heart Attack (Myocard...
Cardiovascular system

High evidence
69.0%

Mercury Contaminant risk & protective factor
Mercury
Contaminant

Cardiovascular Disease Cardiovascular outcome
Strong increased risk of Cardiovascular Disease
Cardiovascular system

High evidence
190.0%

Mercury Contaminant risk & protective factor
Mercury
Contaminant

Mortality Musculoskeletal outcome
Strong increased risk of Mortality
Musculoskeletal system

High evidence
130.0%

Mercury Contaminant risk & protective factor
Mercury
Contaminant

Blood Pressure - Hypertension Cardiovascular outcome
Increased risk of Blood Pressure - Hype...
Cardiovascular system

Low evidence
46.0%

Arsenic Contaminant risk & protective factor
Arsenic
Contaminant

Cardiovascular Disease Cardiovascular outcome
Increased risk of Cardiovascular Disease
Cardiovascular system

Moderate evidence
65.0%

Arsenic Contaminant risk & protective factor
Arsenic
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Increased risk of Coronary Heart Diseas...
Cardiovascular system

Moderate evidence
71.0%

Arsenic Contaminant risk & protective factor
Arsenic
Contaminant

Stroke Brain outcome
Strong increased risk of Stroke
Brain system

Moderate evidence
203.0%