Associations of job strain and lifestyle risk factors with risk of coronary artery disease: a meta-analysis of individual participant data

13 May 2013Mika Kivimäki, PhD, Solja T. Nyberg, MSc, Eleonor I. Fransson, PhD, Katriina Heikkilä, PhD, Lars Alfredsson, PhD, Annalisa Casini, PhD, Els Clays, PhD, Dirk De Bacquer, PhD, Nico Dragano, PhD, Jane E. Ferrie, PhD, Marcel Goldberg, MD, Mark Hamer, PhD, Markus Jokela, PhD, Robert Karasek, PhD, France Kittel, PhD, Anders Knutsson, MD, Markku Koskenvuo, MD, Maria Nordin, PhD, Tuula Oksanen, PhD, Jaana Pentti, BSc, Reiner Rugulies, PhD, Paula Salo, PhD, Johannes Siegrist, PhD, Sakari B. Suominen, MD, Töres Theorell, MD, Jussi Vahtera, MD, Marianna Virtanen, PhD, Peter J.M. Westerholm, MD, Hugo Westerlund, PhD, Marie Zins, MD, Andrew Steptoe, DSc, Archana Singh-Manoux, PhD, G. David Batty, PhD for the IPD-Work Consortium

The risk of coronary artery disease was highest among participants who reported job strain and an unhealthy lifestyle; those with job strain and a healthy lifestyle had half the rate of disease. A healthy lifestyle may substantially reduce disease risk among people with job strain.

Meta Analysis
5 effects
7 years
102 subjects

Reported Outcomes

CausesOutcomeCertainty

Job Stress Brain outcome
Job Stress
Brain system

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Increased risk of Coronary Heart Diseas...
Cardiovascular system

High evidence
25.0%

Smoking Contaminant risk & protective factor
Smoking
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Strong increased risk of Coronary Heart Diseas...
Cardiovascular system

High evidence
115.0%

Alcohol Beverage risk & protective factor
Alcohol
Beverage

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Minor increase risk of Coronary Heart Diseas...
Cardiovascular system

High evidence
22.0%

Sedentary Lifestyle Selfcare risk & protective factor

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Increased risk of Coronary Heart Diseas...
Cardiovascular system

High evidence
56.0%

Obesity Musculoskeletal outcome
Obesity
Musculoskeletal system

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Increased risk of Coronary Heart Diseas...
Cardiovascular system

High evidence
66.0%