A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study

28 Jan 2008Bisjwajit Auddy, PhD, Jayaram Hazra, PhD, Achintya Mitra, MD, Bruce Abedon, PhD, Shibnath Ghosal, PhD

Chronically stressed people taking an ashwagandha extract for 60 days saw improvements with regard to anxiety, well-being, and serum health parameters. Cortisol decreased (by 14.5% for 125 mg/day, 24.2% for 250 mg/day, and 30.5% for 500 mg/day), as did LDL-C (by 17.4% for 500 mg/day) and VLDL-C (by 23.9% for 500 mg/day), while HDL-C increased (by 17.3% for 500 mg/day).

Randomized Controlled Trial
9 effects
6 months
98 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Ashwagandha Herb risk & protective factor
Minor Protective Factor Ashwagandha
Herb

Oxidative stress Lymphatic outcome
Minor decreased risk of Oxidative stress
Lymphatic system

Low evidence
-1.0%

Ashwagandha Herb risk & protective factor
Minor Protective Factor Ashwagandha
Herb

Cortisol Endocrine outcome
Minor decreased risk of Cortisol
Endocrine system

Low evidence
-3.0%

Ashwagandha Herb risk & protective factor
Minor Protective Factor Ashwagandha
Herb

Blood Pressure - Hypertension Cardiovascular outcome
Minor decreased risk of Blood Pressure - Hype...
Cardiovascular system

Moderate evidence
-1.0%

Ashwagandha Herb risk & protective factor
Minor Protective Factor Ashwagandha
Herb

Stress Brain outcome
Minor decreased risk of Stress
Brain system

Low evidence
-244.0%

Ashwagandha Herb risk & protective factor
Minor Protective Factor Ashwagandha
Herb

Heart Rate Cardiovascular outcome
Minor decreased risk of Heart Rate
Cardiovascular system

Moderate evidence
-1.0%

Ashwagandha Herb risk & protective factor
Protective Factor Ashwagandha
Herb

Pain Sensory outcome
Decreased risk of Pain
Sensory system

Low evidence
-600.0%

Ashwagandha Herb risk & protective factor
Strong Protective Factor Ashwagandha
Herb

Sleep Musculoskeletal outcome
Strong increased risk of Sleep
Musculoskeletal system

Moderate evidence
650.0%

Ashwagandha Herb risk & protective factor
Protective Factor Ashwagandha
Herb

Fatigue Musculoskeletal outcome
Decreased risk of Fatigue
Musculoskeletal system

Moderate evidence
-113.0%

Ashwagandha Herb risk & protective factor
Minor Protective Factor Ashwagandha
Herb

Subjective well-being Brain outcome
Minor increase risk of Subjective well-being
Brain system

Low evidence
233.0%