Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

23 Jan 2017Elisa Álvarez Hernández, Sabine Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, Peter Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G. Jones, Johannes Beckers, Martin Hrabě de Angelis, and Michael Roden

Saturated fat ingestion rapidly increases hepatic lipid storage, energy metabolism, and insulin resistance. This is accompanied by regulation of hepatic gene expression and signaling that may contribute to development of nonalcoholic fatty liver disease (NAFLD).

Cohort Study
3 effects
14 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Saturated Fat Nutrition risk & protective factor
Minor Risk Factor Saturated Fat
Nutrition

Insulin Resistance Lymphatic outcome
Minor increase risk of Insulin Resistance
Lymphatic system

Low evidence
25.0%

Saturated Fat Nutrition risk & protective factor
Minor Risk Factor Saturated Fat
Nutrition

Metabolic Syndrome Lymphatic outcome
Minor increase risk of Metabolic Syndrome
Lymphatic system

Low evidence
35.0%

Saturated Fat Nutrition risk & protective factor
Minor Risk Factor Saturated Fat
Nutrition

Non Fatty Liver Disease Digestive outcome
Minor increase risk of Non Fatty Liver Disease
Digestive system

Low evidence
35.0%