Clinical Perspective of Oxidative Stress in Sporadic ALS.

16 Dec 2013D'Amico E, Factor-Litvak P, Santella RM, Mitsumoto H.

Our review indicates that agricultural chemicals, heavy metals, military service, professional sports, excessive physical exertion, chronic head trauma, and certain foods might be modestly associated with ALS risk, with a stronger association between risk and smoking.

Systematic review
18 effects

Reported Outcomes

CausesOutcomeCertainty

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Increased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
90.0%

Concussion (Traumatic Brain Injury) Brain outcome

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
50.0%

Intense Exercise Selfcare risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
70.0%

Saturated Fat Nutrition risk & protective factor
Saturated Fat
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Strong increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
170.0%

Processed Meat Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Strong increased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
220.0%

Cheese Nutrition risk & protective factor
Cheese
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Strong increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
220.0%

Soy Nutrition risk & protective factor
Soy
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Strong increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
220.0%

Walnuts Nutrition risk & protective factor
Walnuts
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Strong increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
220.0%

Tomato Nutrition risk & protective factor
Tomato
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Strong increased risk of Amyotrophic lateral s...
Nervous system

Low evidence
220.0%

Vegetables Nutrition risk & protective factor
Vegetables
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-70.0%

Fruits Nutrition risk & protective factor
Fruits
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-70.0%

Legumes (beans, peas, lentils, lupins) Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-70.0%

Nuts & Peanuts Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-62.0%

Spinach Nutrition risk & protective factor
Spinach
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-62.0%

Purple Sweet Potato Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-62.0%

Avocado Nutrition risk & protective factor
Avocado
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Moderate evidence
-62.0%

Whole grains Nutrition risk & protective factor
Whole grains
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Decreased risk of Amyotrophic lateral s...
Nervous system

Low evidence
-62.0%

Smoking Contaminant risk & protective factor
Smoking
Contaminant

Amyotrophic lateral sclerosis (ALS) Nervous outcome
Increased risk of Amyotrophic lateral s...
Nervous system

High evidence
44.0%