First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study

22 Dec 2016Sandra Hummel, Andreas Beyerlein, Roy Tamura, Ulla Uusitalo, Carin Andrén Aronsson, Jimin Yang, Anne Riikonen, Åke Lernmark, Marian J. Rewers, William A. Hagopian, Jin-Xiong She, Olli G. Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Suvi M. Virtanen, Jill M. Norris, the TEDDY Study Group

These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow’s milk–based infant formula as the first formula in infants at increased genetic risk for T1D (Type 1 Diabetes)

Cohort Study
2 effects
3 months
8676 subjects

Reported Outcomes


Hydrolized formula (Cow Milk) Nutrition risk & protective factor
Risk Factor Hydrolized formula (Co...

Type 1 Diabetes Lymphatic outcome
Increased risk of Type 1 Diabetes
Lymphatic system

High evidence

Cow milk (A1 β-casein) Beverage risk & protective factor
Minor Risk Factor Cow milk (A1 β-casein)

Type 1 Diabetes Lymphatic outcome
Minor increase risk of Type 1 Diabetes
Lymphatic system

Low evidence