Association of Coffee Consumption with Total and Cause-Specific Mortality in Three Large Prospective Cohorts

16 Nov 2015Ming Ding, Ambika Satija, Shilpa N. Bhupathiraju, Yang Hu, Qi Sun, Jiali Han, Esther Lopez-Garcia, Walter Willett, Rob M. van Dam, Frank B. Hu

Higher consumption of total coffee, caffeinated coffee, and decaffeinated coffee was associated with lower risk of total mortality.

Cohort Study

14 effects

22 years

208501 subjects

Determinants	Outcome	Details
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Mortality Musculoskeletal system	Moderate evidence -15.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Cardiovascular Disease Cardiovascular system	Moderate evidence -12.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Prostate Cancer Reproductive system	Moderate evidence -27.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Dementia Brain system	Moderate evidence -31.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Injury Musculoskeletal system	Low evidence -16.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Congestive Heart Failure Cardiovascular system	Moderate evidence -10.0%
Minor Risk Factor Coffee (Caffeine) Beverage	Minor increase risk of Lung cancer Respiratory system	Moderate evidence 39.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Uterine Cancer Reproductive system	Moderate evidence -18.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Suicide Brain system	Low evidence -42.0%
Minor Risk Factor Coffee (Caffeine) Beverage	Minor increase risk of Liver Cancer Digestive system	Moderate evidence 76.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Prostate Cancer Reproductive system	Moderate evidence -27.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Stroke Brain system	Moderate evidence -19.0%
Minor Protective Factor Coffee (Caffeine) Beverage	Minor decreased risk of Diabetes Lymphatic system	Low evidence -35.0%
Minor Risk Factor Coffee (Caffeine) Beverage	Minor increase risk of Pancreatic cancer Digestive system	Moderate evidence 8.0%

Association of Coffee Consumption with Total and Cause-Specific Mortality in Three Large Prospective Cohorts

Reported Outcomes

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of MortalityMusculoskeletal system

Moderate evidence-15.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of Cardiovascular DiseaseCardiovascular system

Moderate evidence-12.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of Prostate CancerReproductive system

Moderate evidence-27.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of DementiaBrain system

Moderate evidence-31.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of InjuryMusculoskeletal system

Low evidence-16.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of Congestive Heart FailureCardiovascular system

Moderate evidence-10.0%

Minor Risk Factor Coffee (Caffeine)Beverage

Minor increase risk of Lung cancerRespiratory system

Moderate evidence39.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of Uterine CancerReproductive system

Moderate evidence-18.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of SuicideBrain system

Low evidence-42.0%

Minor Risk Factor Coffee (Caffeine)Beverage

Minor increase risk of Liver CancerDigestive system

Moderate evidence76.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of Prostate CancerReproductive system

Moderate evidence-27.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of StrokeBrain system

Moderate evidence-19.0%

Minor Protective Factor Coffee (Caffeine)Beverage

Minor decreased risk of DiabetesLymphatic system

Low evidence-35.0%

Minor Risk Factor Coffee (Caffeine)Beverage

Minor increase risk of Pancreatic cancerDigestive system

Moderate evidence8.0%

Risk Factors

Outcomes

About

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Mortality
Musculoskeletal system

Moderate evidence
-15.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Cardiovascular Disease
Cardiovascular system

Moderate evidence
-12.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Prostate Cancer
Reproductive system

Moderate evidence
-27.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Dementia
Brain system

Moderate evidence
-31.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Injury
Musculoskeletal system

Low evidence
-16.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Congestive Heart Failure
Cardiovascular system

Moderate evidence
-10.0%

Minor Risk Factor Coffee (Caffeine)
Beverage

Minor increase risk of Lung cancer
Respiratory system

Moderate evidence
39.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Uterine Cancer
Reproductive system

Moderate evidence
-18.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Suicide
Brain system

Low evidence
-42.0%

Minor Risk Factor Coffee (Caffeine)
Beverage

Minor increase risk of Liver Cancer
Digestive system

Moderate evidence
76.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Prostate Cancer
Reproductive system

Moderate evidence
-27.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Stroke
Brain system

Moderate evidence
-19.0%

Minor Protective Factor Coffee (Caffeine)
Beverage

Minor decreased risk of Diabetes
Lymphatic system

Low evidence
-35.0%

Minor Risk Factor Coffee (Caffeine)
Beverage

Minor increase risk of Pancreatic cancer
Digestive system

Moderate evidence
8.0%