Cumulative Use of Strong Anticholinergics and Incident Dementia A Prospective Cohort Study

01 Feb 2015Shelly L. Gray, PharmD, MS; Melissa L. Anderson, MS; Sascha Dublin, MD, PhD; et al

Higher cumulative anticholinergic use is associated with an increased risk for dementia

Cohort Study
2 effects
12 years
3434 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Antidepressants Manufactured risk & protective factor
Minor Risk Factor Antidepressants
Manufactured

Dementia Brain outcome
Minor increase risk of Dementia
Brain system

Moderate evidence
54.0%

Antidepressants Manufactured risk & protective factor
Minor Risk Factor Antidepressants
Manufactured

Alzheimer's disease Brain outcome
Minor increase risk of Alzheimer's disease
Brain system

Moderate evidence
63.0%