Antipsychotic Use and Risk of Hospitalization or Death Due to Pneumonia in Persons With and Those Without Alzheimer Disease

31 Aug 2016Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen, Heidi Taipale.

Regardless of applied study design, treatment duration, or the choice of drug, the use of antipsychotic agents was associated with a higher risk of pneumonia. With observational data, we cannot fully rule out a shared causality between pneumonia and the use of antipsychotic agents, but the risk to benefit balance should be considered when antipsychotic agents are prescribed.

Cohort Study
2 effects
60584 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Antipsychotics Manufactured risk & protective factor
Strong Risk Factor Antipsychotics
Manufactured

Pneumonia Respiratory outcome
Strong increased risk of Pneumonia
Respiratory system

High evidence
243.0%

Antipsychotics Manufactured risk & protective factor
Risk Factor Antipsychotics
Manufactured

Pneumonia Respiratory outcome
Increased risk of Pneumonia
Respiratory system

High evidence
101.0%