Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium.

14 Mar 2014Prins GS, Hu WY, Shi GB, Hu DP, Majumdar S, Li G, Huang K, Nelles JL, Ho SM, Walker CL, Kajdacsy-Balla A, van Breemen RB.

Together, the present findings demonstrate that human prostate stem-progenitor cells are direct BPA targets and that developmental exposure to BPA at low doses increases hormone-dependent cancer risk in the human prostate epithelium.

Animal Research
1 effect

Reported Outcomes

CausesOutcomeCertainty

Bisphenol A (BPA) Contaminant risk & protective factor

Prostate Cancer Reproductive outcome
Strong increased risk of Prostate Cancer
Reproductive system

Low evidence
153.0%