Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

01 Jul 2016Michael R. Irwin, Richard Olmstead, Judith E. Carroll

Sleep disturbance and long sleep duration, but not short sleep duration, are associated with increases in markers of systemic inflammation.

Meta Analysis
4 effects
50000 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Poor sleep Musculoskeletal outcome
Poor sleep
Musculoskeletal system

Inflammation Lymphatic outcome
Minor increase risk of Inflammation
Lymphatic system

Moderate evidence
20.0%

Long Duration of Sleep Musculoskeletal outcome
Long Duration of Sleep
Musculoskeletal system

Oxidative stress Lymphatic outcome
Minor increase risk of Oxidative stress
Lymphatic system

Moderate evidence
17.0%

Poor sleep Musculoskeletal outcome
Poor sleep
Musculoskeletal system

Oxidative stress Lymphatic outcome
Minor increase risk of Oxidative stress
Lymphatic system

Moderate evidence
12.0%

Long Duration of Sleep Musculoskeletal outcome
Long Duration of Sleep
Musculoskeletal system

Inflammation Lymphatic outcome
Minor increase risk of Inflammation
Lymphatic system

Moderate evidence
11.0%