Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

11 Jan 2017Xinmin S. Li, Slayman Obeid, Roland Klingenberg, Baris Gencer, François Mach, Lorenz Räber, Stephan Windecker, Nicolas Rodondi, David Nanchen, Olivier Muller, Melroy X. Miranda, Christian M. Matter, Yuping Wu, Lin Li, Zeneng Wang, Hassan S. Alamri, Valentin Gogonea, Yoon-Mi Chung, W.H. Wilson Tang, Stanley L. Hazen, Thomas F. Lüscher

Plasma TMAO levels among patients presenting with chest pain predict both near- and long-term risks of incident cardiovascular events, and may thus provide clinical utility in risk stratification among subjects presenting with suspected ACS.

Cohort Study
5 effects
6 months
530 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Trimethylamine N-oxide (TMAO) Digestive outcome
Trimethylamine N-oxid...
Digestive system

Stroke Brain outcome
Strong increased risk of Stroke
Brain system

Moderate evidence
465.0%

Trimethylamine N-oxide (TMAO) Digestive outcome
Trimethylamine N-oxid...
Digestive system

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Minor increase risk of Heart Attack (Myocard...
Cardiovascular system

Moderate evidence
57.0%

Trimethylamine N-oxide (TMAO) Digestive outcome
Trimethylamine N-oxid...
Digestive system

Mortality Musculoskeletal outcome
Minor increase risk of Mortality
Musculoskeletal system

Moderate evidence
81.0%

Trimethylamine N-oxide (TMAO) Digestive outcome
Trimethylamine N-oxid...
Digestive system

Stroke Brain outcome
Minor increase risk of Stroke
Brain system

Moderate evidence
57.0%

Trimethylamine N-oxide (TMAO) Digestive outcome
Trimethylamine N-oxid...
Digestive system

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Strong increased risk of Heart Attack (Myocard...
Cardiovascular system

Moderate evidence
465.0%