Longitudinal Assessment of Chemotherapy-Induced Alterations in Brain Activation During Multitasking and Its Relation With Cognitive Complaints

11 Jan 2017Sabine Deprez, Mathieu Vandenbulcke, Ronald Peeters, Louise Emsell, Ann Smeets, Marie-Rose Christiaens, Frederic Amant, Stefan Sunaert

These results suggest that changes in brain activity may underlie chemotherapy-induced cognitive complaints. The observed changes might be related to chemotherapy-induced damage to the brain or reduced connectivity between brain regions rather than to changes in effort or changes in functional strategy.

Cohort Study
3 effects
6 months
51 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Chemotherapy Manufactured risk & protective factor
Minor Risk Factor Chemotherapy
Manufactured

Anxiety Brain outcome
Minor increase risk of Anxiety
Brain system

Low evidence
188.0%

Chemotherapy Manufactured risk & protective factor
Minor Risk Factor Chemotherapy
Manufactured

Depression Brain outcome
Minor increase risk of Depression
Brain system

Low evidence
105.0%

Chemotherapy Manufactured risk & protective factor
Minor Risk Factor Chemotherapy
Manufactured

Cognitive deficit Brain outcome
Minor increase risk of Cognitive deficit
Brain system

Moderate evidence
38.9%