Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study

11 Jan 2017Dr Ahmed Tawakol, MD, Amorina Ishai, MD, Richard AP Takx, MD, Amparo L Figueroa, MD, Abdelrahman Ali, MD, Yannick Kaiser, BS, Quynh A Truong, MD, Chloe JE Solomon, BS, Claudia Calcagno, MD, Venkatesh Mani, PhD, Cheuk Y Tang, PhD, Prof Willem JM Mulder, PhD, James W Murrough, MD, Prof Udo Hoffmann, MD, Matthias Nahrendorf, MD, Lisa M Shin, PhD, Prof Zahi A Fayad, PhD, Prof Roger K Pitman, MD

In this first study to link regional brain activity to subsequent cardiovascular disease, amygdalar activity independently and robustly predicted cardiovascular disease events. Amygdalar activity is involved partly via a path that includes increased bone-marrow activity and arterial inflammation.

Cross-section study
7 effects
3 years 9 months
293 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Amygdalar activity  Brain outcome

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Minor increase risk of Heart Attack (Myocard...
Cardiovascular system

Moderate evidence
59.0%

Amygdalar activity  Brain outcome

Inflammation Lymphatic outcome
Minor increase risk of Inflammation
Lymphatic system

Moderate evidence
51.0%

Amygdalar activity  Brain outcome

Bone Marrow activity Musculoskeletal outcome
Minor increase risk of Bone Marrow activity
Musculoskeletal system

Moderate evidence
53.0%

Stress Brain outcome
Stress
Brain system

Oxidative stress Lymphatic outcome
Minor increase risk of Oxidative stress
Lymphatic system

Moderate evidence
17.0%

Amygdalar activity  Brain outcome

Stroke Brain outcome
Minor increase risk of Stroke
Brain system

Moderate evidence
59.0%

Stress Brain outcome
Stress
Brain system

Amygdalar activity  Brain outcome
Minor increase risk of Amygdalar activity
Brain system

Moderate evidence
44.0%

Stress Brain outcome
Stress
Brain system

Inflammation Lymphatic outcome
Minor increase risk of Inflammation
Lymphatic system

Moderate evidence
41.0%