Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

12 Mar 2014Sofiya Milman, Gil Atzmon, Derek M. Huffman, Junxiang Wan, Jill P. Crandall, Pinchas Cohen, Nir Barzilai

Lower IGF-1 levels predict longer survival

Meta Analysis
6 effects
184 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Blood Sugar - Hyperglycemia Lymphatic outcome
Minor increase risk of Blood Sugar - Hypergl...
Lymphatic system

Low evidence
33.1%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Type 2 Diabetes Lymphatic outcome
Minor increase risk of Type 2 Diabetes
Lymphatic system

Low evidence
51.7%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Cardiovascular Disease Cardiovascular outcome
Minor increase risk of Cardiovascular Disease
Cardiovascular system

Low evidence
20.45%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Cognitive deficit Brain outcome
Minor decreased risk of Cognitive deficit
Brain system

Low evidence
-6.0%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Mortality Musculoskeletal outcome
Minor decreased risk of Mortality
Musculoskeletal system

Moderate evidence
-6.1%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Cancer Lymphatic outcome
Minor decreased risk of Cancer
Lymphatic system

Moderate evidence
-23.0%