Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice

22 Dec 2016Karen R. Jonscher, Michael S. Stewart, Alba Alfonso-Garcia, Brian C. DeFelice, Xiaoxin X. Wang, Yuhuan Luo, Moshe Levi, Margaret J. R. Heerwagen, Rachel C. Janssen, Becky A. de la Houssaye, Ellen Wiitala, Garrett Florey, Raleigh L. Jonscher, Eric O. Potma, Oliver Fiehn, and Jacob E. Friedman

Our results suggest that supplementation with pyrroloquinoline quinone found in human breast milk, particularly during pregnancy and lactation, protects offspring from Western-style diet -induced developmental programming of hepatic lipotoxicity and may help slow the advancing epidemic of nonalcoholic fatty liver disease in the next generation

Animal Research
2 effects

Reported Outcomes

DeterminantsOutcomeDetails

Western (Northern European) diet Nutrition risk & protective factor
Minor Risk Factor Western (Northern Euro...
Nutrition

Non Fatty Liver Disease Digestive outcome
Minor increase risk of Non Fatty Liver Disease
Digestive system

Low evidence
5.0%

Breastfeeding Selfcare risk & protective factor
Minor Protective Factor Breastfeeding
Selfcare

Non Fatty Liver Disease Digestive outcome
Minor decreased risk of Non Fatty Liver Disease
Digestive system

Low evidence
-7.5%