Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

13 Sep 2016Nikhil K. Khankari, Xiao-Ou Shu, Wanqing Wen, Peter Kraft, Sara Lindström, Ulrike Peters, Joellen Schildkraut, Fredrick Schumacher, Paolo Bofetta, Angela Risch, Heike Bickeböller, Christopher I. Amos, Douglas Easton, Rosalind A. Eeles, Stephen B. Gruber,Christopher A. Haiman, David J. Hunter, Stephen J. Chanock, Brandon L. Pierce, Wei Zheng

Our study provides evidence for a potential causal association of adult height with the risk of colorectal and lung cancers and suggests that certain genetic factors and biological pathways affecting adult height may also affect the risk of these cancers.

Meta Analysis
6 effects
62 subjects

Reported Outcomes

DeterminantsOutcomeDetails

Height Musculoskeletal outcome
Height
Musculoskeletal system

Lung cancer Respiratory outcome
Minor increase risk of Lung cancer
Respiratory system

High evidence
6.0%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Colorectal Cancer Digestive outcome
Minor increase risk of Colorectal Cancer
Digestive system

Low evidence
12.0%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Prostate Cancer Reproductive outcome
Minor increase risk of Prostate Cancer
Reproductive system

Low evidence
7.0%

Insulin-like Human Growth Hormone (IGF-1) Endocrine outcome
Insulin-like Human Gr...
Endocrine system

Lung cancer Respiratory outcome
Minor increase risk of Lung cancer
Respiratory system

Low evidence
6.0%

Height Musculoskeletal outcome
Height
Musculoskeletal system

Colorectal Cancer Digestive outcome
Minor increase risk of Colorectal Cancer
Digestive system

High evidence
12.0%

Height Musculoskeletal outcome
Height
Musculoskeletal system

Prostate Cancer Reproductive outcome
Minor increase risk of Prostate Cancer
Reproductive system

High evidence
7.0%