Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training

24 Oct 2016Yorgi Mavros PhD, Nicola Gates PhD, Guy C. Wilson MSc, Nidhi Jain MPH, Jacinda Meiklejohn BS, Henry Brodaty DSc, Wei Wen PhD, Nalin Singh MBBS, Bernhard T. Baune PhD, Chao Suo PhD, Michael K. Baker PhD, Nasim Foroughi PhD, Yi Wang PhD, Perminder S. Sachdev PhD, Michael Valenzuela PhD, Maria A. Fiatarone Singh MD

High-intensity PRT results in significant improvements in cognitive function, muscle strength, and aerobic capacity in older adults with MCI. Strength gains, but not aerobic capacity changes, mediate the cognitive benefits of PRT. Future investigations are warranted to determine the physiological mechanisms linking strength gains and cognitive benefits.

Randomized Controlled Trial
2 effects
6 months
100 subjects

Reported Outcomes


Strength Training Selfcare risk & protective factor

Cognitive deficit Brain outcome
Minor decreased risk of Cognitive deficit
Brain system

Moderate evidence

Strength Training Selfcare risk & protective factor

Strength Musculoskeletal outcome
Minor increase risk of Strength
Musculoskeletal system

High evidence