Physical Activity and Incident Type 2 Diabetes Mellitus: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

17 Oct 2016Andrea D. Smith, Alessio Crippa, James Woodcock, Søren Brage

Our results suggest an overall non-linear relationship; using the cubic spline model we found a risk reduction of 26% (95% CI 20%, 31%) for type 2 diabetes among those who achieved 11.25 MET h/week (equivalent to 150 min/week of moderate activity) relative to inactive individuals. Achieving twice this amount of PA was associated with a risk reduction of 36% (95% CI 27%, 46%), with further reductions at higher doses (60 MET h/week, risk reduction of 53%)

Higher levels of LTPA were associated with substantially lower incidence of type 2 diabetes in the general population. The relationship between LTPA and type 2 diabetes was curvilinear; the greatest relative benefits are achieved at low levels of activity, but additional benefits can be realised at exposures considerably higher than those prescribed by public health recommendations.

Systematic review
1 effect

Reported Outcomes


Moderate Exercise Selfcare risk & protective factor
Protective Factor Moderate Exercise

Type 2 Diabetes Lymphatic outcome
Decreased risk of Type 2 Diabetes
Lymphatic system

High evidence