Diabetes Mellitus and the Incidence of Colorectal Cancer: An Updated Systematic Review and Meta-Analysis

17 Feb 2012Longying DengZhifu GuiLianying ZhaoJianping WangLizong ShenEmail author

findings further support a relationship between diabetes and increased risk of colon and rectal cancer in both women and men, and insulin therapy for diabetes may increase this risk.

Meta Analysis
3 effects
3659341 subjects

Reported Outcomes

CausesOutcomeCertainty

Artificial Insulin Manufactured risk & protective factor
Artificial Insulin
Manufactured

Colorectal Cancer Digestive outcome
Increased risk of Colorectal Cancer
Digestive system

Moderate evidence
61.0%

Type 2 Diabetes Lymphatic outcome
Type 2 Diabetes
Lymphatic system

Colorectal Cancer Digestive outcome
Increased risk of Colorectal Cancer
Digestive system

High evidence
26.0%

Type 1 Diabetes Lymphatic outcome
Type 1 Diabetes
Lymphatic system

Colorectal Cancer Digestive outcome
Increased risk of Colorectal Cancer
Digestive system

High evidence
26.0%