Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies

15 Jan 2013Mark J Nieuwenhuijsen, Payam Dadvand, James Grellier, David Martinez and Martine Vrijheid

Findings report statistically significant negative associations between environmental exposures such as environmental tobacco smoke, air pollution and chemicals and pregnancy outcomes

Meta Analysis

13 effects

Determinants	Outcome	Details
Minor Protective Factor Indoor Air Pollution Contaminant	Minor increase risk of Low birth weight Maternity system	Moderate evidence 38.0%
Minor Protective Factor Polychlorinated Biphen... Contaminant	Minor increase risk of Low birth weight Maternity system	Moderate evidence 1.0%
Minor Protective Factor PM25 Outdoor Air Pollu... Contaminant	Minor increase risk of Low birth weight Maternity system	Low evidence 1.0%
Minor Protective Factor PM10 Outdoor Air Pollu... Contaminant	Minor increase risk of Low birth weight Maternity system	Moderate evidence 14.0%
Minor Risk Factor Smoking Contaminant	Minor increase risk of Congenital Anomaly Maternity system	High evidence 17.0%
Minor Risk Factor Passive Smoking Contaminant	Minor increase risk of Congenital Anomaly Maternity system	High evidence 13.0%
Risk Factor Chlorination disinfect... Contaminant	Increased risk of Congenital Anomaly Maternity system	High evidence 59.0%
Risk Factor Agent orange Contaminant	Increased risk of Congenital Anomaly Maternity system	High evidence 95.0%
Minor Risk Factor Smoking Contaminant	Minor increase risk of Still Birth Maternity system	High evidence 23.0%
Risk Factor Indoor Air Pollution Contaminant	Increased risk of Still Birth Maternity system	High evidence 51.0%
Protective Factor Smoking Contaminant	Increased risk of Low birth weight Maternity system	High evidence 32.0%
Risk Factor Solvents Exposure Contaminant	Increased risk of Congenital Anomaly Maternity system	High evidence 47.0%
Risk Factor Pesticides Exposure Contaminant	Increased risk of Congenital Anomaly Maternity system	High evidence 37.0%

Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies

Reported Outcomes

Minor Protective Factor Indoor Air PollutionContaminant

Minor increase risk of Low birth weightMaternity system

Moderate evidence38.0%

Minor Protective Factor Polychlorinated Biphen...Contaminant

Minor increase risk of Low birth weightMaternity system

Moderate evidence1.0%

Minor Protective Factor PM25 Outdoor Air Pollu...Contaminant

Minor increase risk of Low birth weightMaternity system

Low evidence1.0%

Minor Protective Factor PM10 Outdoor Air Pollu...Contaminant

Minor increase risk of Low birth weightMaternity system

Moderate evidence14.0%

Minor Risk Factor SmokingContaminant

Minor increase risk of Congenital AnomalyMaternity system

High evidence17.0%

Minor Risk Factor Passive SmokingContaminant

Minor increase risk of Congenital AnomalyMaternity system

High evidence13.0%

Risk Factor Chlorination disinfect...Contaminant

Increased risk of Congenital AnomalyMaternity system

High evidence59.0%

Risk Factor Agent orangeContaminant

Increased risk of Congenital AnomalyMaternity system

High evidence95.0%

Minor Risk Factor SmokingContaminant

Minor increase risk of Still BirthMaternity system

High evidence23.0%

Risk Factor Indoor Air PollutionContaminant

Increased risk of Still BirthMaternity system

High evidence51.0%

Protective Factor SmokingContaminant

Increased risk of Low birth weightMaternity system

High evidence32.0%

Risk Factor Solvents ExposureContaminant

Increased risk of Congenital AnomalyMaternity system

High evidence47.0%

Risk Factor Pesticides ExposureContaminant

Increased risk of Congenital AnomalyMaternity system

High evidence37.0%

Risk Factors

Outcomes

About

Minor Protective Factor Indoor Air Pollution
Contaminant

Minor increase risk of Low birth weight
Maternity system

Moderate evidence
38.0%

Minor Protective Factor Polychlorinated Biphen...
Contaminant

Minor increase risk of Low birth weight
Maternity system

Moderate evidence
1.0%

Minor Protective Factor PM25 Outdoor Air Pollu...
Contaminant

Minor increase risk of Low birth weight
Maternity system

Low evidence
1.0%

Minor Protective Factor PM10 Outdoor Air Pollu...
Contaminant

Minor increase risk of Low birth weight
Maternity system

Moderate evidence
14.0%

Minor Risk Factor Smoking
Contaminant

Minor increase risk of Congenital Anomaly
Maternity system

High evidence
17.0%

Minor Risk Factor Passive Smoking
Contaminant

Minor increase risk of Congenital Anomaly
Maternity system

High evidence
13.0%

Risk Factor Chlorination disinfect...
Contaminant

Increased risk of Congenital Anomaly
Maternity system

High evidence
59.0%

Risk Factor Agent orange
Contaminant

Increased risk of Congenital Anomaly
Maternity system

High evidence
95.0%

Minor Risk Factor Smoking
Contaminant

Minor increase risk of Still Birth
Maternity system

High evidence
23.0%

Risk Factor Indoor Air Pollution
Contaminant

Increased risk of Still Birth
Maternity system

High evidence
51.0%

Protective Factor Smoking
Contaminant

Increased risk of Low birth weight
Maternity system

High evidence
32.0%

Risk Factor Solvents Exposure
Contaminant

Increased risk of Congenital Anomaly
Maternity system

High evidence
47.0%

Risk Factor Pesticides Exposure
Contaminant

Increased risk of Congenital Anomaly
Maternity system

High evidence
37.0%