Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies

15 Jan 2013Mark J Nieuwenhuijsen, Payam Dadvand, James Grellier, David Martinez and Martine Vrijheid

Findings report statistically significant negative associations between environmental exposures such as environmental tobacco smoke, air pollution and chemicals and pregnancy outcomes

Meta Analysis
13 effects

Reported Outcomes

CausesOutcomeCertainty

Indoor Air Pollution Contaminant risk & protective factor

Low birth weight Maternity outcome
Increased risk of Low birth weight
Maternity system

Moderate evidence
38.0%

Polychlorinated Biphenyl (PCB)  Contaminant risk & protective factor

Low birth weight Maternity outcome
Minor increase risk of Low birth weight
Maternity system

Moderate evidence
1.0%

PM25 Outdoor Air Pollution Contaminant risk & protective factor

Low birth weight Maternity outcome
Minor increase risk of Low birth weight
Maternity system

Low evidence
1.0%

PM10 Outdoor Air Pollution Contaminant risk & protective factor

Low birth weight Maternity outcome
Minor increase risk of Low birth weight
Maternity system

Moderate evidence
14.0%

Smoking Contaminant risk & protective factor
Smoking
Contaminant

Congenital Anomaly Maternity outcome
Minor increase risk of Congenital Anomaly
Maternity system

High evidence
17.0%

Passive Smoking Contaminant risk & protective factor
Passive Smoking
Contaminant

Congenital Anomaly Maternity outcome
Minor increase risk of Congenital Anomaly
Maternity system

High evidence
13.0%

Chlorination disinfection byproducts (DBPs) - Water contaminant Contaminant risk & protective factor

Congenital Anomaly Maternity outcome
Increased risk of Congenital Anomaly
Maternity system

High evidence
59.0%

Agent orange Contaminant risk & protective factor
Agent orange
Contaminant

Congenital Anomaly Maternity outcome
Increased risk of Congenital Anomaly
Maternity system

High evidence
95.0%

Smoking Contaminant risk & protective factor
Smoking
Contaminant

Still Birth Maternity outcome
Minor increase risk of Still Birth
Maternity system

High evidence
23.0%

Indoor Air Pollution Contaminant risk & protective factor

Still Birth Maternity outcome
Increased risk of Still Birth
Maternity system

High evidence
51.0%

Smoking Contaminant risk & protective factor
Smoking
Contaminant

Low birth weight Maternity outcome
Increased risk of Low birth weight
Maternity system

High evidence
32.0%

Solvents Exposure Contaminant risk & protective factor

Congenital Anomaly Maternity outcome
Increased risk of Congenital Anomaly
Maternity system

High evidence
47.0%

Pesticides Exposure Contaminant risk & protective factor

Congenital Anomaly Maternity outcome
Increased risk of Congenital Anomaly
Maternity system

High evidence
37.0%