Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure

16 Dec 2014Natalia V. Solenkova, MD, PhD, Jonathan D. Newman, MD, MPH, Jeffrey S. Berger, MD, MS, George Thurston, ScD, Judith S. Hochman, MD, Gervasio A. Lamas, MD

There is strong evidence that xenobiotic metal contamination is linked to atherosclerotic disease and cardiovascular disease and is a modifiable risk factor.

Meta Analysis
19 effects
60000 subjects

Reported Outcomes

VariablesOutcomeEffectLatency

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Cardiovascular Disease Cardiovascular outcome
Cardiovascular ...
Cardiovascular

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Heart Attack (M...
Cardiovascular

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Coronary Heart ...
Cardiovascular

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Stroke Brain outcome
Stroke
Brain

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Mortality Musculoskeletal outcome
Mortality
Musculoskeletal

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Mortality Musculoskeletal outcome
Mortality
Musculoskeletal

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Blood Pressure - Hypertension Cardiovascular outcome
Blood Pressure ...
Cardiovascular

Notable Increase

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Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Mortality Musculoskeletal outcome
Mortality
Musculoskeletal

Strong Increase

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Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Heart Attack (M...
Cardiovascular

Strong Increase

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Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Coronary Heart ...
Cardiovascular

Strong Increase

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Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Cardiovascular Disease Cardiovascular outcome
Cardiovascular ...
Cardiovascular

Strong Increase

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Cadmium Contaminant risk & protective factor
Cadmium
Contaminant

Stroke Brain outcome
Stroke
Brain

Strong Increase

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Mercury Contaminant risk & protective factor
Mercury
Contaminant

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Heart Attack (M...
Cardiovascular

Strong Increase

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Mercury Contaminant risk & protective factor
Mercury
Contaminant

Cardiovascular Disease Cardiovascular outcome
Cardiovascular ...
Cardiovascular

Strong Increase

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Mercury Contaminant risk & protective factor
Mercury
Contaminant

Mortality Musculoskeletal outcome
Mortality
Musculoskeletal

Strong Increase

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Mercury Contaminant risk & protective factor
Mercury
Contaminant

Blood Pressure - Hypertension Cardiovascular outcome
Blood Pressure ...
Cardiovascular

Strong Increase

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Arsenic Contaminant risk & protective factor
Arsenic
Contaminant

Cardiovascular Disease Cardiovascular outcome
Cardiovascular ...
Cardiovascular

Strong Increase

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Arsenic Contaminant risk & protective factor
Arsenic
Contaminant

Coronary Heart Disease (Ischaemic Heart Disease) Cardiovascular outcome
Coronary Heart ...
Cardiovascular

Strong Increase

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Arsenic Contaminant risk & protective factor
Arsenic
Contaminant

Stroke Brain outcome
Stroke
Brain

Strong Increase

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