Clinical Perspective of Oxidative Stress in Sporadic ALS.

16 Dec 2013D'Amico E, Factor-Litvak P, Santella RM, Mitsumoto H.

Our review indicates that agricultural chemicals, heavy metals, military service, professional sports, excessive physical exertion, chronic head trauma, and certain foods might be modestly associated with ALS risk, with a stronger association between risk and smoking.

Systematic review
18 effects

Reported Outcomes

VariablesOutcomeEffectLatency

Lead Exposure Contaminant risk & protective factor
Lead Exposure
Contaminant

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Concussion (Traumatic Brain Injury) Brain outcome

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Intense Exercise Selfcare risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Saturated Fat Nutrition risk & protective factor
Saturated Fat
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Processed Meat Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Cheese Nutrition risk & protective factor
Cheese
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Soy Nutrition risk & protective factor
Soy
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Walnuts Nutrition risk & protective factor
Walnuts
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Tomato Nutrition risk & protective factor
Tomato
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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Vegetables Nutrition risk & protective factor
Vegetables
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Fruits Nutrition risk & protective factor
Fruits
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Legumes (beans, peas, lentils, lupins) Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Nuts & Peanuts Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Spinach Nutrition risk & protective factor
Spinach
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Purple Sweet Potato Nutrition risk & protective factor

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Avocado Nutrition risk & protective factor
Avocado
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Whole grains Nutrition risk & protective factor
Whole grains
Nutrition

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Decrease

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Smoking Contaminant risk & protective factor
Smoking
Contaminant

Amyotrophic lateral sclerosis (ALS) Nervous outcome

Strong Increase

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