Longitudinal Assessment of Chemotherapy-Induced Alterations in Brain Activation During Multitasking and Its Relation With Cognitive Complaints

11 Jan 2017Sabine Deprez, Mathieu Vandenbulcke, Ronald Peeters, Louise Emsell, Ann Smeets, Marie-Rose Christiaens, Frederic Amant, Stefan Sunaert

These results suggest that changes in brain activity may underlie chemotherapy-induced cognitive complaints. The observed changes might be related to chemotherapy-induced damage to the brain or reduced connectivity between brain regions rather than to changes in effort or changes in functional strategy.

Cohort Study
3 effects
6 months
51 subjects

Reported Outcomes

CausesOutcomeCertainty

Chemotherapy Manufactured risk & protective factor
Chemotherapy
Manufactured

Anxiety Brain outcome
Strong increased risk of Anxiety
Brain system

Evidence: Low
188.0%

Chemotherapy Manufactured risk & protective factor
Chemotherapy
Manufactured

Depression Brain outcome
Strong increased risk of Depression
Brain system

Evidence: Low
105.0%

Chemotherapy Manufactured risk & protective factor
Chemotherapy
Manufactured

Cognitive deficit Brain outcome
Strong increased risk of Cognitive deficit
Brain system

Evidence: Moderate
38.9%