Risk of Acute Thromboembolic Events With Oral Contraceptive Use: A Systematic Review and Meta-analysis

12 Aug 2013Peragallo Urrutia, Rachel MD, MSCR; Coeytaux, Remy R. MD, PhD; McBroom, Amanda J. PhD; Gierisch, Jennifer M. PhD, MPH; Havrilesky, Laura J. MD, MHSc; Moorman, Patricia G. PhD; Lowery, William J. MD; Dinan, Michaela PhD; Hasselblad, Vic PhD; Sanders, Gillian D. PhD; Myers, Evan R. MD, MPH

Current use of combined oral contraceptive pills is associated with increased odds of venous thromboembolism and ischemic stroke but not hemorrhagic stroke or MI.

Meta Analysis
3 effects

Reported Outcomes

CausesOutcomeCertainty

Contraceptive pills Manufactured risk & protective factor

Thrombosis Cardiovascular outcome
Strong increased risk of Thrombosis
Cardiovascular system

Evidence: Very High
197.0%

Contraceptive pills Manufactured risk & protective factor

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Strong increased risk of Heart Attack (Myocardia...
Cardiovascular system

Evidence: Low
34.0%

Contraceptive pills Manufactured risk & protective factor

Stroke Brain outcome
Strong increased risk of Stroke
Brain system

Evidence: Very High
90.0%