Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review

18 Nov 2013Jennifer M. Gierisch, Remy R. Coeytaux, Rachel Peragallo Urrutia, Laura J. Havrilesky, Patricia G. Moorman, William J. Lowery, Michaela Dinan, Amanda J. McBroom, Vic Hasselblad, Gillian D. Sanders and Evan R. Myers

ompared with never use, ever use of oral contraceptives is significantly associated with decreases in colorectal and endometrial cancers and increases in breast cancers. Although elevated breast cancer risk was small, relatively high incidence of breast cancers means that oral contraceptives may contribute to a substantial number of cases.

Systematic review
4 effects
10 years

Reported Outcomes

CausesOutcomeCertainty

Contraceptive pills Manufactured risk & protective factor

Colorectal Cancer Digestive outcome
Minor decreased risk of Colorectal Cancer
Digestive system

Evidence: Moderate
-14.0%

Contraceptive pills Manufactured risk & protective factor

Breast Cancer Reproductive outcome
Minor increase risk of Breast Cancer
Reproductive system

Evidence: Very High
8.0%

Contraceptive pills Manufactured risk & protective factor

Uterine Cancer Reproductive outcome
Decreased risk of Uterine Cancer
Reproductive system

Evidence: Very High
-43.0%

Contraceptive pills Manufactured risk & protective factor

Central Nervous System Cancer Brain outcome
Minor increase risk of Central Nervous System ...
Brain system

Evidence: Moderate
9.0%