Multivitamins in the Prevention of Cardiovascular Disease in Men The Physicians' Health Study II Randomized Controlled Trial

07 Nov 2012Howard D. Sesso, ScD, MPH; William G. Christen, ScD; Vadim Bubes, PhD;

Among this population of US male physicians, taking a daily multivitamin did not reduce major cardiovascular events, MI, stroke, and CVD mortality after more than a decade of treatment and follow-up.

Randomized Controlled Trial
4 effects
14 years
14 subjects

Reported Outcomes

CausesOutcomeCertainty

Dietary supplements and vitamins Manufactured risk & protective factor

Cardiovascular Disease Cardiovascular outcome
Minor increase risk of Cardiovascular Disease
Cardiovascular system

Evidence: Very High
0.0%

Dietary supplements and vitamins Manufactured risk & protective factor

Mortality Musculoskeletal outcome
Minor increase risk of Mortality
Musculoskeletal system

Evidence: Very High
0.0%

Dietary supplements and vitamins Manufactured risk & protective factor

Stroke Brain outcome
Minor increase risk of Stroke
Brain system

Evidence: Very High
0.0%

Dietary supplements and vitamins Manufactured risk & protective factor

Heart Attack (Myocardial infarction - ACS) Cardiovascular outcome
Minor increase risk of Heart Attack (Myocardia...
Cardiovascular system

Evidence: Very High
0.0%