Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials

19 Jul 2016 Imamura F, Micha R, Wu JHY, de Oliveira Otto MC, Otite FO, Abioye AI, et al. (2016) Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials

The findings suggest exchanging dietary carbohydrate with saturated fat does not appreciably influence markers of blood glucose control.
On the other hand, substituting carbohydrate and saturated fat with a diet rich in unsaturated fat, particularly polyunsaturated fat, was beneficial for the regulation of blood sugar.

Systematic review
5 effects
4220 subjects

Reported Outcomes

CausesOutcomeCertainty

Unsaturated fat Nutrition risk & protective factor

Insulin Resistance Lymphatic outcome
Minor decreased risk of Insulin Resistance
Lymphatic system

Evidence: Very High
-2.4%

Unsaturated fat Nutrition risk & protective factor

Blood Sugar - Hyperglycemia Lymphatic outcome
Minor decreased risk of Blood Sugar - Hyperglyc...
Lymphatic system

Evidence: Very High
-1.0%

Unsaturated fat Nutrition risk & protective factor

Cardiovascular Disease Cardiovascular outcome
Minor decreased risk of Cardiovascular Disease
Cardiovascular system

Evidence: Low
-6.8%

Ketogenic diet Nutrition risk & protective factor

Insulin Resistance Lymphatic outcome
Minor decreased risk of Insulin Resistance
Lymphatic system

Evidence: Very High
-2.4%

Unsaturated fat Nutrition risk & protective factor

Type 2 Diabetes Lymphatic outcome
Minor decreased risk of Type 2 Diabetes
Lymphatic system

Evidence: Low
-22.0%